MedSpa 501 — Chapel Hill, North Carolina
Confidence: Inside and Out.
Personalized anti-aging and wellness solutions — blending cutting-edge aesthetic treatments with functional medicine in Chapel Hill's most trusted medspa.
- Best Spa — Chapel Hill Magazine 2025
- Multi-provider expert team
- Aesthetics + functional wellness
Chapel Hill, North Carolina · Refined, natural-looking outcomes.
Featured treatments
A curated set of services tailored to your goals.
Botox, Xeomin & Daxxify
Most requestedNeuromodulators to soften fine lines and wrinkles naturally.
MedSpa 501 offers Botox, Xeomin, and Daxxify — three leading neuromodulators that relax the muscles causing dynamic lines and wrinkles. Daxxify is the longest-lasting option at 6+ months. All treatments are customized for natural, refreshed results.
Dermal Fillers
Restore volume, smooth lines, and enhance facial contours.
Dermal fillers restore lost volume, smooth static lines, and enhance facial features including lips, cheeks, jawline, and under-eyes. Our providers use a conservative, artful approach for natural-looking results.
IV Nutrient Therapy
Replenish, hydrate, and energize from the inside out.
IV nutrient therapy delivers vitamins, minerals, and hydration directly into the bloodstream for full absorption. MedSpa 501 offers customized IV formulations designed in partnership with 501 Pharmacy.
Medical Weight Loss
GLP-1 and medically supervised weight loss programs.
MedSpa 501 offers medically supervised weight loss programs including GLP-1 based treatments. All programs are personalized and monitored by licensed providers for safe, sustainable results.
Facials & Microneedling
Advanced skin treatments for a healthy, radiant complexion.
MedSpa 501 offers HydraFacials, customized facials, and microneedling (SkinStylus) to improve skin texture, tone, hydration, and radiance. Treatments are tailored to your specific skin type and concerns.
PRF
Platelet-rich fibrin for natural skin rejuvenation and hair restoration.
PRF uses your body's own growth factors to stimulate collagen, improve skin quality, and support hair restoration. A natural regenerative treatment with no synthetic additives and progressive results over weeks.
Why choose MedSpa 501
Award-winning care from an expert team in Chapel Hill.
Expert multi-provider team
Board-certified physicians, nurse practitioners, physician associates, nurse injectors, and licensed aestheticians — each bringing deep expertise and a personalized approach.
Aesthetics meets wellness
MedSpa 501 offers more than surface treatments — IV therapy, functional wellness, medical weight loss, and peptide therapy sit alongside injectables and advanced skin care.
Award-winning care
Voted Best Spa and Best New Business by Chapel Hill Magazine in 2025. Trusted by the Triangle community since opening.
OUR TEAM
Meet Your Providers
Every treatment at MedSpa 501 is performed by licensed professionals. You will always know who is caring for you.
Josh Dobstaff, MD
Physician & Co-Founder
Board-certified physician and hospitalist with over a decade of experience. Specializes in medical weight loss, hormone optimization, and regenerative health.
Allie Vivirito, RN, BSN
Co-Founder & Nurse
Healthcare leader with over 16 years of nursing experience. Degrees from Virginia Tech and Johns Hopkins. Passionate about reducing barriers to wellness.
Samantha Danesi, PA-C, LMT
Physician Associate
Board-certified PA with over 17 years of experience in aesthetic medicine, plastic surgery, and dermatology. Known for artful, natural-looking injectable results.
Holly Meehan, RN, BSN
Nurse Injector
Certified nurse injector with a background in orthopedic and reconstructive plastic surgery at UNC. Works closely with each client to meet their individual goals.
Kristin Timpy, MSN, APRN, IFMCP
Nurse Practitioner
Board-certified nurse practitioner with nearly two decades of experience in cardiology, family medicine, and functional medicine. Institute for Functional Medicine certified provider.
Brittany Duval
Aesthetician
Licensed aesthetician with over a decade of experience specializing in chemical peels, microneedling, and customized facials.
Results gallery
Believable outcomes that still look like you.
Injectables: Natural refinement
Skin rejuvenation: Texture & tone
Photos are representative. Individual results vary.
What clients say
A few words from guests who trust MedSpa 501.
“My least painful injections ever — and that is without topical numbing. Samantha is highly educated in aesthetic procedures and facial anatomy. She listened well, offered her recommendations with no pressure, and carried out the procedures in an expert and gentle manner.”
“I love MedSpa 501. The staff is knowledgeable and personable. They will not push extra services on you. They want what is the best for you and your budget. I am 51 and feel my skin is in the best shape it has ever been.”
“Holly took the time to thoroughly explain the process and the different options available, which made me feel really comfortable and informed. The HydraFacial itself was incredible — my skin feels so clean, refreshed, and glowing.”
Testimonials reflect individual experiences. Results may vary.
Chapel Hill's trusted medspa
MedSpa 501 was founded on the belief that aging well is a choice — and that true confidence starts from within. Our multi-provider team blends the art of aesthetics with the science of wellness, delivering personalized care tailored to your unique goals. Founded by Franklin Roye, Allie Vivirito, Greg Vassie, Josh Dobstaff MD, and Han Su, MedSpa 501 brings together healthcare leadership, pharmacy expertise, and clinical excellence under one roof.
- Best Spa + Best New Business — Chapel Hill Magazine 2025
- Partnered with 501 Pharmacy for custom IV and skincare formulations
- Multi-provider team with deep aesthetic and wellness expertise
FAQ
Quick answers to common questions.
Who performs treatments at MedSpa 501?
Treatments are performed by our licensed team including physicians, nurse practitioners, physician associates, nurse injectors, and licensed aestheticians. Every treatment is matched to the right provider for your goals.
Do you offer consultations?
Yes. New clients are encouraged to start with a consultation so we can understand your goals and recommend the right treatment plan. Book online or call (984) 336-0501.
What neuromodulators do you offer?
We offer Botox, Xeomin, and Daxxify. Daxxify is our longest-lasting option with results typically lasting 6 months or more. All three are customized for natural results.
Do you offer memberships?
Yes. We offer The Glow Collective memberships: GlowTox (quarterly neuromodulator treatments, $2,200/year) and SkinGlow (monthly skin treatments, $2,000/year). Both include 15% savings on skincare and require a 3-month minimum commitment.
Do you offer medical weight loss?
Yes. We offer GLP-1 based medical weight loss programs supervised by our licensed providers including Dr. Josh Dobstaff, MD.
What is IV nutrient therapy?
IV therapy delivers vitamins, minerals, and hydration directly into the bloodstream for full absorption. Our formulations are custom-designed in partnership with 501 Pharmacy.
What are your hours?
Monday through Friday: 9am to 6pm. Saturday and Sunday: Closed.
Where are you located?
69 Knox Way, Suite 108, Chapel Hill, NC 27516.
How do I book?
Book online through our Boulevard portal, call (984) 336-0501, or email hello@medspa501.com.
From the MedSpa 501 Journal
Short, educational notes to help you plan treatments and feel more prepared for your visit.
Facial Balancing with Injectables: The Art of Subtle, Sculpted Symmetry
Want to look more refreshed, sculpted, and camera-ready without looking overdone? Facial balancing uses fillers and neurotoxins to create subtle, natural harmony.
Non-Surgical Hip and Booty Contouring: Sculpt Your Curves Without Surgery
Non-surgical body contouring is having a major moment. Learn how filler-based enhancement can add shape and volume without surgery.
The Rise of Functional Medicine and Medicine 3.0: Why More People Are Turning to Root-Cause Wellness
Healthcare is changing. More people are moving away from rushed, symptom-based care and toward personalized, root-cause wellness.